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Gene Expression Data
Assay Details
Assay
Reference: J:290862 Fulmer D, et al., Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin. Dev Biol. 2020 Jul 1;463(1):26-38
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6718501
Gene symbol: Dhh
Gene name: desert hedgehog
Antibody: Anti-Dhh Antibody (F-9): sc-271168
Detection system: Secondary antibody
Results
Specimen 1D E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: mitral valve Present Regionally restricted 1D E13.5 upper , 1D E13.5 lower Expressed in valve endocardium with the highest signal present at the valve tip, more concentrated along the atrialis with evidence of protein diffusion into the interstitium.
TS21: visceral pericardium Present 1D E13.5 upper
TS21: heart endothelium Present Regionally restricted 1D E13.5 upper Expressed in ventricular endothelium.
Specimen 1D E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: mitral valve Present Regionally restricted 1D E15.5 upper , 1D E15.5 lower Expressed in valve endocardium with the highest signal present at the valve tip, more concentrated along the atrialis with evidence of protein diffusion into the interstitium.
TS23: visceral pericardium Present 1D E15.5 upper
Specimen 1D P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: mitral valve Present Regionally restricted 1D P0 lower , 1D P0 upper Expressed in valve endocardium with the highest signal present at the valve tip, more concentrated along the atrialis with evidence of protein diffusion into the interstitium.
TS27: visceral pericardium Present 1D P0 upper
Specimen 1D 6 months: postnatal month 6 (more )
Structure Level Pattern Image Note
TS28: mitral valve Absent 1D 6 months lower , 1D 6 months upper
Specimen S1A: postnatal day 0; Dhhtm1Ics/Dhh+ (more )
Structure Level Pattern Image Note
TS27: endocardial lining Present Regionally restricted S1A Expressed in valve endocardium with the highest signal present at the valve tip.
TS27: mitral valve Present Regionally restricted S1A Expressed in valve endocardium with the highest signal present at the valve tip.
Specimen S1B: postnatal day 0; Dhhtm1Ics/Dhhtm1Ics, Tg(Tek-cre)1Ywa/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: endocardial lining Absent S1B
TS27: mitral valve Absent S1B
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory