Tg(Tcra31.2.10,Tcrb31.2.10)7Kejm
Transgene Detail
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| Symbol: |
Tg(Tcra31.2.10,Tcrb31.2.10)7Kejm |
| Name: |
transgene insertion 7, Kevin J Maloy |
| MGI ID: |
MGI:6718328 |
| Synonyms: |
Tg7 |
| Transgene: |
Tg(Tcra31.2.10,Tcrb31.2.10)7Kejm Location: unknown
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| Alliance: |
Tg(Tcra31.2.10,Tcrb31.2.10)7Kejm page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Tcra31.2.10,Tcrb31.2.10)7Kejm expresses
2 genes
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Mutation details: The transgene comprises the MHC class II (I-Ab)-restricted TCR specific for a peptide derived from the glycoprotein (G) of vesicular stomatitis virus (VSV), derived from T cell hybridoma 31.2.10.4 (leader sequence (L), the rearranged Va4, JaTA72, Ca). The TCR sequence was preceded by the H2-Kb promoter and followed by beta globin intron 2, poly(A) signal sequences and an Igh enhancer. This construct was co-injected with a construct containing a VSV-IND-G-specific, I-Ab-restricted, Vb2+ 31.2.10 T cell hybridoma-derived Tcrb gene (leader, Vb2, Db1.1, Jb2.1, Cb2) with the same upstream and downstream sequences.
(J:114743)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:114743 Maloy KJ, et al., Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection. J Immunol. 1999 Mar 1;162(5):2867-74 |
| All: |
2 reference(s) |
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Analysis Tools
