Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Grem1tm1.1(cre/ERT2)Snjt
Name:	gremlin 1, DAN family BMP antagonist; targeted mutation 1.1, Shannon J Turley
MGI ID:	MGI:6718253
Synonyms:	Grem1-CreERT2
Gene:	Grem1  Location: Chr2:113579020-113588993 bp, - strand  Genetic Position: Chr2, 57.43 cM
Alliance:	Grem1tm1.1(cre/ERT2)Snjt page

Germline Transmission:	Earliest citation of germline transmission: J:305302
Parent Cell Line:	C2 (Nagy) (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Grem1tm1.1(cre/ERT2)Snjt expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Grem1 (MGI:1344337)   Mutation details: The targeting construct introduced in exon2 after ATG, CreERT2-SV40-FRT-pgk-neo-FRT. Flp-mediated recombination removed the selection cassette. (J:305302)

Activity:	Tissue activity of this recombinase allele
Driver:	Grem1 (mouse) Summary of all recombinase alleles driven by Grem1. Comparative matrix view of recombinase activities Alliance mouse Grem1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grem1 Mutation:	16 strains or lines available

Original:	J:305302 Kapoor VN, et al., Gremlin 1(+) fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues. Nat Immunol. 2021 May;22(5):571-585
All:	1 reference(s)