Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Hexbem2(cre/ERT2)Mp
Name:	hexosaminidase B; endonuclease-mediated mutation 2, Marco Prinz
MGI ID:	MGI:6717342
Synonyms:	HexbCreERT2
Gene:	Hexb  Location: Chr13:97312839-97334865 bp, - strand  Genetic Position: Chr13, 50.66 cM
Alliance:	Hexbem2(cre/ERT2)Mp page

Strain of Origin:

C57BL/6N

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Hexbem2(cre/ERT2)Mp expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Hexb (MGI:96074)   Mutation details: CRISPR/Cas9 system was used to knockin the T2A-cre/ERT2 cassette into the Hexb locus by injecting mouse embryos on a C57Bl/6N background. (J:306642)

Activity:	Tissue activity of this recombinase allele
Driver:	Hexb (mouse) Summary of all recombinase alleles driven by Hexb. Comparative matrix view of recombinase activities Alliance mouse Hexb gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hexb Mutation:	91 strains or lines available

Original:	J:306642 Masuda T, et al., Novel Hexb-based tools for studying microglia in the CNS. Nat Immunol. 2020 Jul;21(7):802-815
All:	3 reference(s)