Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Nanog-cre/Esr1*)4470Mms
Name:	transgene insertion 4470, Michael Shen
MGI ID:	MGI:6714092
Synonyms:	Tg(Nanog-cre/ERT2)4470Mms
Transgene:	Tg(Nanog-cre/Esr1*)4470Mms  Location: unknown
Alliance:	Tg(Nanog-cre/Esr1*)4470Mms page

Strain of Origin:

C57BL/6N

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Nanog-cre/Esr1*)4470Mms expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Nanog (MGI:1919200)   Mutation details: The bacterial artificial chromosome, RP23-406B15, containing Nanog and its regulatory sequences was modified to insert a cDNA encoding Cre/Esr1* fusion protein into the translation initiation start site. Additional sequencing indicates that the fusion is not ERT2, but appears to be a mutant derivative of the mouse estrogen receptor. (J:248397)

Activity:	Tissue activity of this recombinase allele
Driver:	Nanog (mouse) Summary of all recombinase alleles driven by Nanog. Comparative matrix view of recombinase activities Alliance mouse Nanog gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:248397 Talos F, et al., A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue. Nat Commun. 2017 Apr 21;8:14662
All:	1 reference(s)