About   Help   FAQ
Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas Vollrath
MGI ID: MGI:6711969
Synonyms: Rosa26BEST1-CreERT2
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:305495
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  STOCK Gt(ROSA)26Sortm12Luo/Luo
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold expression driven by 1 gene
 
Mutation details: The allele was created to have the human BEST1 promoter/enhancer regions directing the expression of a CreER(T2) fusion gene. The targeting vector contained, from 5' to 3', the human BEST1 promoter (nucleotides -585 to +38), followed by a CreER(T2) fusion gene, and an SV40 a polyA cassette. The plasmid was pronuclear injected into C57BL/6J(attPx3) zygotes along with phiC31 integrase mRNA. The resulting founder mice were bred with C57BL/6J for germline transmission. (J:305495)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: BEST1 (human)
Summary of all recombinase alleles driven by BEST1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  1051 strains or lines available
Notes
This allele was produced in zygotes collected from mice carrying the Gt(ROSA)26Sortm12Luo allele, which was generated in (129X1/SvJ x 129S1/Sv)F1-Kitl+)-derived R1 ES cells on a mixed background with 129S1/SvJ, 129X1/SvJ, C57BL/6J, and DBA/2J.
References
Original:  J:305495 Chen M, et al., An efficient inducible RPE-Selective cre transgenic mouse line. Exp Eye Res. 2021 Jan;202:108370
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory