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Gene Expression Data
Assay Details
Assay
Reference: J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6711803
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175) (#9661)
Detection system: Secondary antibody coupled to DyLight
Results
Specimen not shown - control: embryonic day 12.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Pax2tm1.1Akio/Pax2+, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: nephrogenic zone Present Single cells Expression is seen in apopotic cells.
Specimen not shown - CM KO: embryonic day 12.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Pax2tm1.1Akio/Pax2tm1.2Akio, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: nephrogenic zone Present Single cells Expression is seen in apopotic cells; their number is increased in the mutant.
Specimen 3K: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Pax2tm1.1Akio/Pax2+, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: green - cleaved Casp3; red - Cre reporter; white - cytokeratin
Structure Level Pattern Image Note
TS21: nephrogenic zone Present Single cells 3K Expression is seen in apopotic cells.
Specimen 3L: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, Pax2tm1.1Akio/Pax2tm1.2Akio, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: green - cleaved Casp3; red- Cre reporter; white - cytokeratin
Structure Level Pattern Image Note
TS21: nephrogenic zone Present Single cells 3L Expression is seen in apopotic cells; there is a 8.95 fold increase in their number in the mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
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