Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Fgf15tm1.1(cre)Thor
Name:	fibroblast growth factor 15; targeted mutation 1.1, Bernard Thorens
MGI ID:	MGI:6711269
Synonyms:	Fgf15CretdT
Gene:	Fgf15  Location: Chr7:144450269-144454690 bp, + strand  Genetic Position: Chr7, 88.92 cM
Alliance:	Fgf15tm1.1(cre)Thor page

Germline Transmission:	Earliest citation of germline transmission: J:305713
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Recombinase, Reporter) Mutation:    Insertion   Fgf15tm1.1(cre)Thor expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Fgf15 (MGI:1096383)   Mutation details: A T2A-cre-T2A-tdTomato cassette was introduced just before the stop codon in exon 3 of the mouse Fgf15 gene via homologous recombination in embryonic stem (ES) cells. An FRT-flanked PGK-neomycin cassette located 3' of the stop codon was excised through crosses with Flp recombinase-expressing mice. (J:305713)

Activity:	Tissue activity of this recombinase allele
Driver:	Fgf15 (mouse) Summary of all recombinase alleles driven by Fgf15. Comparative matrix view of recombinase activities Alliance mouse Fgf15 gene page

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf15 Mutation:	15 strains or lines available

Original:	J:305713 Picard A, et al., Fgf15 neurons of the dorsomedial hypothalamus control glucagon secretion and hepatic gluconeogenesis. Diabetes. 2021 Apr 21;
All:	1 reference(s)