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Gene Expression Data
Assay Details
Assay
Reference: J:286303 Buckley DM, et al., Gbx1 and Gbx2 Are Essential for Normal Patterning and Development of Interneurons and Motor Neurons in the Embryonic Spinal Cord. J Dev Biol. 2020 Apr 1;8(2)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6705109
Gene symbol: Casp3
Gene name: caspase 3
Antibody: Anti-Caspase3
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 4A: embryonic day 12.5 (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS20: spinal cord Present 4A
Specimen 4B: embryonic day 12.5; Gbx1tm1.1Stwt/Gbx1tm1.1Stwt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS20: spinal cord Present 4B The Gbx1 mutant showed no difference in apoptotic activity in the dorsal or ventral spinal cord compared to control at E12.5.
Specimen 4C: embryonic day 12.5; Gbx2tm1.1Mrt/Gbx2tm1.1Mrt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS20: spinal cord Present 4C The Gbx2 mutant showed no difference in apoptotic activity in the dorsal or ventral spinal cord compared to control at E12.5.
Specimen 4D: embryonic day 12.5; Gbx1tm1.1Stwt/Gbx1tm1.1Stwt, Gbx2tm1.1Mrt/Gbx2tm1.1Mrt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS20: spinal cord Present 4D The Gbx dKO mutant showed no difference in apoptotic activity in the dorsal or ventral spinal cord compared to control at E12.5.
Specimen 4E: embryonic day 13.5 (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS21: spinal cord Present Single cells 4E A few Casp3-positive cells were observed in the ventral spinal cord of the control embryo.
Specimen 4F: embryonic day 13.5; Gbx1tm1.1Stwt/Gbx1tm1.1Stwt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS21: spinal cord Present Regionally restricted 4F The level of apoptosis significantly increased in the ventral spinal cord in the Gbx1 mutant when compared to control.
Specimen 4G: embryonic day 13.5; Gbx2tm1.1Mrt/Gbx2tm1.1Mrt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS21: spinal cord Present Regionally restricted 4G The level of apoptosis significantly increased in the ventral spinal cord in the Gbx2 mutant when compared to control.
Specimen 4H: embryonic day 13.5; Gbx1tm1.1Stwt/Gbx1tm1.1Stwt, Gbx2tm1.1Mrt/Gbx2tm1.1Mrt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS21: spinal cord Present Regionally restricted 4H The level of apoptosis appears augmented at E13.5 in the ventral spinal cord in the Gbx dKO mutant when compared to each single Gbx mutant.
Specimen 4I: embryonic day 14.5 (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS22: spinal cord ventral horn Present Single cells 4I A few Casp3-positive cells were observed in the ventral spinal cord of the control embryo.
Specimen 4J: embryonic day 14.5; Gbx1tm1.1Stwt/Gbx1tm1.1Stwt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS22: spinal cord ventral horn Present Regionally restricted 4J The level of apoptosis significantly increased in the ventral spinal cord in the Gbx1 mutant when compared to control.
Specimen 4K: embryonic day 14.5; Gbx2tm1.1Mrt/Gbx2tm1.1Mrt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS22: spinal cord ventral horn Absent 4K
Specimen 4L: embryonic day 14.5; Gbx1tm1.1Stwt/Gbx1tm1.1Stwt, Gbx2tm1.1Mrt/Gbx2tm1.1Mrt (more )
Note: Lumbar spinal cord.
Structure Level Pattern Image Note
TS22: spinal cord ventral horn Present Regionally restricted 4L The level of apoptosis significantly increased in the ventral spinal cord in the Gbx dKO mutant when compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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