Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Tc(HSA17*N279K)1Mdk
Name:	transchromosomal, human 17, line 1, Michael Koob; transchromosomal, human 17, line 1, Michael D Koob
MGI ID:	MGI:6705043
Synonyms:	MAPT(H1.0*N279K)-GR
Gene:	Tc(HSA17*N279K)1Mdk  Location: unknown  Genetic Position: Chr11, Syntenic
Alliance:	Tc(HSA17*N279K)1Mdk page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	PRX-B6N (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intergenic deletion, Nucleotide substitutions   Tc(HSA17*N279K)1Mdk expresses 2 genes Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human MAPT (4137) Mapt  (MGI:97180) MAPT*N279K human SPPL2C (162540) Sppl2c  (MGI:3045264)   Mutation details: A 157 kb deletion on mouse chromosome 11 stretching from, but not including, Crhr1 to Kansl1 is replaced by a syntenic 190 kb region from human chromosome 17 (HSA17). The mouse Sppl2c (signal peptide peptidase 2C) and Mapt (microtubule-associated protein tau) genes are replaced by human SPPL2C and MAPT (H1 haplotype) genes. The human MAPT gene was modified to include the N279K (asparaginine to lysine) mutation identified in FTD patients. A loxN-flanked neomycin resistance cassette that was removed by transient cre expression. (J:101977)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tc(HSA17*N279K)1Mdk Mutation:	1 strain or line available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	1 reference(s)