Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Terttm4(cre/ERT2)Sear
Name:	telomerase reverse transcriptase; targeted mutation 4, Steven E Artandi
MGI ID:	MGI:6704920
Synonyms:	TertCreERT2
Gene:	Tert  Location: Chr13:73775030-73797962 bp, + strand  Genetic Position: Chr13, 40.12 cM
Alliance:	Terttm4(cre/ERT2)Sear page

Germline Transmission:	Earliest citation of germline transmission: J:261807
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Terttm4(cre/ERT2)Sear expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tert (MGI:1202709)   Mutation details: The targeting vector was generated by inserting a codon-optimized intron-CreERT2-NeoR cassette into the endogenous translational start site of Tert in the BAC (RP24-342O18) via recombineering. The targeting vector was linearized and electroporated into JM8/F6 mouse ES cells. Correctly targeted ES clones were selected by Southern blotting and karyotypes, and then injected into ICR/CD-1 blastocysts to generate the knock-in line. (J:261807)

Activity:	Tissue activity of this recombinase allele
Driver:	Tert (mouse) Summary of all recombinase alleles driven by Tert. Alliance mouse Tert gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tert Mutation:	52 strains or lines available

Original:	J:261807 Lin S, et al., Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature. 2018 Apr;556(7700):244-248
All:	2 reference(s)