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Gene Expression Data
Assay Details
Assay
Reference: J:135698 Burlison JS, et al., Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol. 2008 Apr 1;316(1):74-86
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6695725
Gene symbol: Pdx1
Gene name: pancreatic and duodenal homeobox 1
Reporter: lacZ
Direct Detection
Results
Specimen 3A (left): embryonic day 12.5; Pdx1tm2Cvw/Pdx1+, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS20: common bile duct Present 3A (left)
TS20: duodenum Present 3A (left)
TS20: hepatic duct extrahepatic part Present 3A (left)
TS20: stomach Present 3A (left)
TS20: pancreas Present Regionally restricted 3A (left) Dorsal pancreas is associated with duodenum. Ventral pancreas is evaginating from common bile duct epithelium. Lobes have fused at their proximal ends near the duodenum.
Specimen 3A (right): embryonic day 12.5; Pdx1tm2Cvw/Pdx1+, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS20: common bile duct Present 3A (right)
TS20: cystic duct Present 3A (right)
TS20: duodenum Present 3A (right)
TS20: stomach Present 3A (right)
TS20: pancreas Present Regionally restricted 3A (right) Dorsal pancreas is associated with duodenum. Ventral pancreas is evaginating from common bile duct epithelium. Lobes have fused at their proximal ends near the duodenum.
Specimen 3B (left): embryonic day 15.5; Pdx1tm2Cvw/Pdx1+, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS23: pancreas Present Regionally restricted 3B (left) Normal epithelial branching and lobulation indicates acinar development. Ventral pancreas is present.
Specimen 3B (right): embryonic day 15.5; Pdx1tm2Cvw/Pdx1+, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS23: common bile duct Present 3B (right)
TS23: hepatic duct extrahepatic part Present 3B (right)
TS23: pancreas Present Regionally restricted 3B (right) Normal epithelial branching and lobulation indicates acinar development. Ventral pancreas is present.
Specimen 3C (left): embryonic day 12.5; Pdx1tm2Cvw/Pdx1+, Ptf1atm2.1Mgn/Ptf1atm2.1Mgn (more )
Structure Level Pattern Image Note
TS20: duodenum Present 3C (left)
TS20: hepatic duct extrahepatic part Present 3C (left)
TS20: stomach Present 3C (left)
TS20: pancreas Present Regionally restricted 3C (left) At E12.5, epithelium of dorsal pancreatic remnant is growth deficient and does not branch. Fusion of dorsal and ventral lobes did not occur. Ventral pancreatic remnant is barely discernable.
Specimen 3C (right): embryonic day 12.5; Pdx1tm2Cvw/Pdx1+, Ptf1atm2.1Mgn/Ptf1atm2.1Mgn (more )
Structure Level Pattern Image Note
TS20: common bile duct Present Regionally restricted 3C (right)
TS20: cystic duct Present Regionally restricted 3C (right)
TS20: duodenum Present Regionally restricted 3C (right)
TS20: gallbladder Present Regionally restricted 3C (right)
TS20: stomach Present Regionally restricted 3C (right)
TS20: pancreas Present 3C (right) At E12.5, epithelium of dorsal pancreatic remnant is growth deficient and does not branch. Fusion of dorsal and ventral lobes did not occur. Ventral pancreatic remnant is barely discernable.
Specimen 3D (left): embryonic day 15.5; Pdx1tm2Cvw/Pdx1+, Ptf1atm2.1Mgn/Ptf1atm2.1Mgn (more )
Structure Level Pattern Image Note
TS23: pancreas Present Regionally restricted 3D (left) Expression in dorsal pancreatic remnant which is minimally branched and extends from the duodenum towards the spleen. Ventral pancreatic remnant is absent.
Specimen 3D (right): embryonic day 15.5; Pdx1tm2Cvw/Pdx1+, Ptf1atm2.1Mgn/Ptf1atm2.1Mgn (more )
Structure Level Pattern Image Note
TS23: common bile duct Present 3D (right)
TS23: hepatic duct extrahepatic part Present 3D (right)
TS23: pancreas Present Regionally restricted 3D (right) Expression in dorsal pancreatic remnant which is minimally branched and extends from the duodenum towards the spleen. Ventral pancreatic remnant is absent.
Specimen 3E (left): embryonic day 12.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS20: duodenum Present 3E (left)
TS20: hepatic duct extrahepatic part Present 3E (left)
TS20: stomach Present 3E (left)
TS20: pancreas Present Regionally restricted 3E (left) Considerably smaller dorsal pancreatic remnant than Pdx1 null embryos at same stage, while displaying a similar structure.
Specimen 3E (right): embryonic day 12.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS20: common bile duct Present 3E (right)
TS20: cystic duct Present 3E (right)
TS20: duodenum Present 3E (right)
TS20: gallbladder Present 3E (right)
TS20: stomach Present 3E (right)
TS20: pancreas Present Regionally restricted 3E (right) Authors report discernment of ventral pancreatic remnant from adjacent common bile duct is questionable.
Specimen 3F (left): embryonic day 15.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS23: pancreas Present Regionally restricted 3F (left) Pancreas undergoes limited branching. Ventral pancreatic remnant not evident.
Specimen 3F (right): embryonic day 15.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS23: common bile duct Present 3F (right)
TS23: pancreas Present Regionally restricted 3F (right) Pancreas undergoes limited branching. Ventral pancreatic remnant not evident.
Specimen LacZko/LacZko;YFP/+ E15.5 not shown: embryonic day 15.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1a+ (more )
Structure Level Pattern Image Note
TS23: cystic duct Strong Expression more intense in gallbladder and cystic duct.
TS23: gallbladder Strong Expression more intense in gallbladder and cystic duct.
Specimen 3G (left): embryonic day 12.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1atm2.1Mgn (more )
Structure Level Pattern Image Note
TS20: duodenum Present 3G (left) Morphological phenotype identical to that of Pdx1-null embryos.
TS20: hepatic duct extrahepatic part Present 3G (left) Morphological phenotype identical to that of Pdx1-null embryos.
TS20: stomach Present 3G (left) Morphological phenotype identical to that of Pdx1-null embryos.
TS20: pancreas Present 3G (left) Morphological phenotype identical to that of Pdx1-null embryos.
Specimen 3G (right): embryonic day 12.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1atm2.1Mgn (more )
Structure Level Pattern Image Note
TS20: common bile duct Present 3G (right) Morphological phenotype identical to that of Pdx1-null embryos.
TS20: cystic duct Present 3G (right) Morphological phenotype identical to that of Pdx1-null embryos.
TS20: duodenum Present 3G (right) Morphological phenotype identical to that of Pdx1-null embryos.
TS20: gallbladder Present 3G (right) Morphological phenotype identical to that of Pdx1-null embryos.
TS20: stomach Present 3G (right) Morphological phenotype identical to that of Pdx1-null embryos.
TS20: pancreas Present 3G (right) Morphological phenotype identical to that of Pdx1-null embryos.
Specimen 3H (left): embryonic day 15.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1atm2.1Mgn (more )
Structure Level Pattern Image Note
TS23: pancreas Present Regionally restricted 3H (left) Expression in dorsal pancreatic remnant. No ventral pancreatic remnant.
Specimen 3H (right): embryonic day 15.5; Pdx1tm2Cvw/Pdx1tm2Cvw, Ptf1atm2.1Mgn/Ptf1atm2.1Mgn (more )
Structure Level Pattern Image Note
TS23: common bile duct Present 3H (right)
TS23: pancreas Present Regionally restricted 3H (right) Expression in dorsal pancreatic remnant. No ventral pancreatic remnant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory