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Gene Expression Data
Assay Details
Assay
Reference: J:96395 Lee S, et al., Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth. Hum Mol Genet. 2005 Mar 1;14(5):627-37
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6514715
Gene symbol: L1cam
Gene name: L1 cell adhesion molecule
Antibody: anti-NCAM L1 (clone 324)
Detection system: Secondary antibody coupled to Texas Red
Results
Specimen 5D: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: forebrain Present Regionally restricted 5D Expression was detected in thalamocortical tracts.
Specimen 5D': embryonic day 16.5; Ndntm2Stw/Ndn+ (more )
Note: Specimen carried a paternally inherited necdin deficiency and was functionally necdin null.
Structure Level Pattern Image Note
TS24: forebrain Present Regionally restricted 5D' Expression was detected in the reduced thalamocortical axons and in the mutant ectopic axon bundle in the anterior hypothalamic region dorsolateral to the optic chiasm and rostral to the zona incerta and lateral hypothalamus.
TS24: corpus striatum Present Regionally restricted 5D' Expression was detected in ectopic axonal whorls in the striatum of necdin null embryos.
Specimen 6H: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS22: dorsal thalamus Present 6H
Specimen 6H': embryonic day 13.5; Ndntm2Stw/Ndn+ (more )
Note: Specimen carried a paternally inherited necdin deficiency and was functionally necdin null.
Structure Level Pattern Image Note
TS22: dorsal thalamus Present Regionally restricted 6H' Aberrant staining was noted in the ventral region of the necdin null dorsal thalamus.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory