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Gene Expression Data
Assay Details
Assay
Reference: J:239610 Taniguchi K, et al., Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning. Eur J Hum Genet. 2017 Feb;25(2):208-215
Assay type: RNA in situ
MGI Accession ID: MGI:6513211
Gene symbol: Pax2
Gene name: paired box 2
Probe: Pax2 probe39
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 3b control: embryonic day 9.75 (more )
Structure Level Pattern Image Note
TS16: eye Present 3b control bottom , 3b control top Expression is in the two eye fields.
Specimen 3b cdKO: embryonic day 9.75; Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: eye Weak 3b cdKO bottom , 3b cdKO top There is a single band of expression in this mutant and it is not separated into the two separate eye fields as seen in control embryos.
Specimen 3b Nodal+/z;cdKO: embryonic day 9.75; Nodaltm1Rob/Nodal+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: eye Present 3b Nodal+/z;cdKO top , 3b Nodal+/z;cdKO bottom There is a single band of expression in this mutant and it is not separated into the two separate eye fields as seen in control embryos.
Specimen 3b Gli3+/r;cdKO: embryonic day 9.75; Gli3tm1Alj/Gli3+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: eye Present 3b Gli3+/r;cdKO bottom , 3b Gli3+/r;cdKO top There is a single band of expression in this mutant and it is not separated into the two separate eye fields as seen in control embryos.
Specimen 3b G3+/r;N+/z;cdKO: embryonic day 9.75; Gli3tm1Alj/Gli3+, Nodaltm1Rob/Nodal+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: eye Present 3b G3+/r;N+/z;cdKO top , 3b G3+/r;N+/z;cdKO bottom Expression in this mutant is in the two eye fields similar as in control embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory