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Tg(Fap-TK)MRkl
Transgene Detail
Summary
Symbol: Tg(Fap-TK)MRkl
Name: transgene insertion M, Raghu Kalluri
MGI ID: MGI:6509143
Synonyms: FAP-TK
Transgene: Tg(Fap-TK)MRkl  Location: unknown  
Alliance: Tg(Fap-TK)MRkl page
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgenic construct contains a 5 kb sequence including the Fap (fibroblast activation protein) promoter and part of exon 1 inserted into the pORF-HSV1-TK vector, which contains the full coding sequence of the Herpes simplex virus thymidine kinase. (J:325566)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:325566 McAndrews KM, et al., Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer. Cancer Discov. 2022 Jun 2;12(6):1580-1597
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory