Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Adora1em1(cre)Rei
Name:	adenosine A1 receptor; endonuclease-mediated mutation 1, Marc L Reitman
MGI ID:	MGI:6509134
Synonyms:	Adora1-Cre
Gene:	Adora1  Location: Chr1:134126963-134163169 bp, - strand  Genetic Position: Chr1, 58.15 cM, cytoband E4
Alliance:	Adora1em1(cre)Rei page

Strain of Origin:

(C57BL/6 x DBA)F1

Allele Type:    Endonuclease-mediated (Recombinase) Mutation:    Insertion   Adora1em1(cre)Rei expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Adora1 (MGI:99401)   Mutation details: CRISPR/cas9 genome editing is used to insert a T2A peptide sequence and Cre recombinase at the stop codon. T2A sequence adds EGRGSLLTCGDVEENPG to the C terminus of Adora1 and a proline to the N terminus of cre. (J:300669)

Activity:	Tissue activity of this recombinase allele
Driver:	Adora1 (mouse) Summary of all recombinase alleles driven by Adora1. Comparative matrix view of recombinase activities Alliance mouse Adora1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora1 Mutation:	22 strains or lines available

Original:	J:300669 Province HS, et al., Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms. PLoS One. 2020;15(12):e0243986
All:	1 reference(s)