Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ace2tm1.1(ACE2)Mdk
Name:	angiotensin converting enzyme 2; targeted mutation 1.1, Michael Koob
MGI ID:	MGI:6509009
Synonyms:	ACE2-GR
Gene:	Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Alliance:	Ace2tm1.1(ACE2)Mdk page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	PRX-B6N (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Ace2tm1.1(ACE2)Mdk expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human ACE2 (59272) Ace2  (MGI:1917258)   Mutation details: The targeting vector is designed to replace 71 kb (70,987bp) on the mouse X chromosome stretching from, but not including, collectrin, amino acid transport regulator (Cltrn) gene to BMX non-receptor tyrosine kinase (Bmx) gene with a syntenic 66 kb (65,812bp) region from the human X chromosome. A loxN-flanked neomycin resistance (neo) cassette was inserted at the junction between the human ACE2 and mouse Bmx genes. Transient cre-mediated recombination removed the floxed neo cassette. (J:101977)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:	54 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	1 reference(s)