Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Scxtm2.1(cre/ERT2)Stzr
Name:	scleraxis scleraxis bHLH transcription factor; targeted mutation 2.1, Ronen Schweitzer
MGI ID:	MGI:6508700
Synonyms:	Scxcre/ERT2, ScxCreERT2
Gene:	Scx  Location: Chr15:76341652-76343658 bp, + strand  Genetic Position: Chr15, 35.92 cM
Alliance:	Scxtm2.1(cre/ERT2)Stzr page

Germline Transmission:	Earliest citation of germline transmission: J:268613
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Scxtm2.1(cre/ERT2)Stzr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Scx (MGI:102934)   Mutation details: An IRES-CreERT2 sequence was inserted between the stop codon and 3 UTR in exon 2. The construct also contained a FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the neo cassette. (J:268613, J:299624)

Activity:	Tissue activity of this recombinase allele
Driver:	Scx (mouse) Summary of all recombinase alleles driven by Scx. Comparative matrix view of recombinase activities Alliance mouse Scx gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scx Mutation:	12 strains or lines available

Original:	J:268613 Howell K, et al., Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing. Sci Rep. 2017 Mar 23;7:45238
All:	8 reference(s)