Tg(TcraD78,TcrbD78)#Wrh
Transgene Detail
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| Symbol: |
Tg(TcraD78,TcrbD78)#Wrh |
| Name: |
transgene insertion, William R Heath |
| MGI ID: |
MGI:6508696 |
| Synonyms: |
PbT-II |
| Transgene: |
Tg(TcraD78,TcrbD78)#Wrh Location: unknown
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| Alliance: |
Tg(TcraD78,TcrbD78)#Wrh page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(TcraD78,TcrbD78)#Wrh expresses
2 genes
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Mutation details: Transgenic Plasmodium berghei ANKA strain (PbA) MHC II-restricted (H2-Ab1 (H2-IAb)) TCR (PbT-II) mice were generated using the V(D)J segments of the Tcra and Tcrb genes of a CD4+ T cell hybridoma (D78) specific for an unidentified blood-stage PbA antigen. The D78 hybridoma is derived from a T cell line isolated from a blood-stage PbA-infected C57BL/6 mouse. The Tcra chain consists of V2.7, J12, and C gene segments and the Tcrb chain of V12, D2, and J2.4. The transgene also contains the Igh chain enhancer, the H2-K1 (H2-Kb) promoter and the polyadenylation signal sequence of the human beta-globulin gene for the Tcra segments and the Tcrb enhancer, the 2B4-derived 5' region and leader sequence and the B3-derived promoter and coding regions for the Tcrb segments.
(J:256756)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:256756 Fernandez-Ruiz D, et al., Development of a Novel CD4(+) TCR Transgenic Line That Reveals a Dominant Role for CD8(+) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria. J Immunol. 2017 Dec 15;199(12):4165-4179 |
| All: |
2 reference(s) |
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Analysis Tools
