Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Cxcl12-icre/ERT2)L289Nono
Name:	transgene insertion L289, Noriaki Ono
MGI ID:	MGI:6508084
Synonyms:	Cxcl12-creER
Transgene:	Tg(Cxcl12-icre/ERT2)L289Nono  Location: unknown  Genetic Position: ChrUN, Syntenic
Alliance:	Tg(Cxcl12-icre/ERT2)L289Nono page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Cxcl12-icre/ERT2)L289Nono expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Cxcl12 (MGI:103556)   Mutation details: The bacterial artificial chromosome, RP23-22F6, containing 74 kb upstream and 121 kb downstream genomic sequences of the Cxcl12 gene was modified to insert (codon improved) icre/ERT2 fusion followed by bovine growth hormone and polyA cDNA into the first exon. (J:286719)

Activity:	Tissue activity of this recombinase allele
Driver:	Cxcl12 (mouse) Summary of all recombinase alleles driven by Cxcl12. Comparative matrix view of recombinase activities Alliance mouse Cxcl12 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:286719 Matsushita Y, et al., A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nat Commun. 2020 Jan 16;11(1):332
All:	1 reference(s)