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Gene Expression Data
Assay Details
Assay
Reference: J:33032 Schorle H, et al., Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature. 1996 May 16;381(6579):235-8
Assay type: RNA in situ
MGI Accession ID: MGI:6507850
Gene symbol: Tfap2a
Gene name: transcription factor AP-2, alpha
Probe: AP-2 probe10
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 4a left: embryonic day 8.25 (more )
Structure Level Pattern Image Note
TS13: future hindbrain Strong 4a left
TS13: future midbrain Strong 4a left
TS13: future prosencephalon Strong 4a left
TS13: migrating neural crest Strong 4a left
Specimen 4a right: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: neural fold Strong Regionally restricted 4a right Expressed in cranial folds.
TS13: neural crest Strong Regionally restricted 4a right Expressed in the trigeminal neural crest cells.
Specimen 4b WT: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch Strong 4b left
TS15: 2nd branchial arch Strong 4b left
TS15: migrating neural crest Strong 4b left
TS15: rhombomere 1 Strong 4b left
TS15: rhombomere 2 Strong 4b left
TS15: rhombomere 4 Strong 4b left
Specimen 4b -/-: embryonic day 9.5; Tfap2atm1Jae/Tfap2atm1Jae (more )
Structure Level Pattern Image Note
TS15: neural fold Present 4b right Greatly reduced expression compared with the wild-type, correlated with failed cranial closure.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory