Tg(PCSK9)1Prat
Transgene Detail
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| Symbol: |
Tg(PCSK9)1Prat |
| Name: |
transgene insertion 1, Annik Prat |
| MGI ID: |
MGI:6507712 |
| Synonyms: |
Tg(RP11-55M23-AbsI)1Prat |
| Transgene: |
Tg(PCSK9)1Prat Location: unknown
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| Alliance: |
Tg(PCSK9)1Prat page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(PCSK9)1Prat expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PCSK9 (255738) |
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Mutation details: The transgene consists of the human RP11-55M23 BAC, which includes the entire PCSK9 gene flanked with 35.5 kb and 7 kb of upstream and downstream DNA, respectively. Four founder lines were established, with line 4 having the highest expression.
(J:302051)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:302051 Essalmani R, et al., A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice. Biol Chem. 2018;399(12):1363-1374 |
| All: |
2 reference(s) |
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Analysis Tools
