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Gene Expression Data
Assay Details
Assay
Reference: J:217439 Srinivasan RS, et al., The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev. 2014 Oct 1;28(19):2175-87
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6507018
Gene symbol: Flt4
Gene name: FMS-like tyrosine kinase 4
Results
Specimen S2E: embryonic day 15.5; Flt4tm1Ali/Flt4+ (more )
Note: Triple labeled: red - Vegfr3 (Flt4); green - Prox1 (assay MGI:6507015); blue - Lyve1 (assay MGI:6507020).
Structure Level Pattern Image Note
TS23: lymphatic system Present Regionally restricted S2E
TS23: skin Present Regionally restricted S2E
Specimen S2F: embryonic day 15.5; Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: red - Vegfr3 (Flt4); green - Prox1 (assay MGI:6507015); blue - Lyve1 (assay MGI:6507020).
Structure Level Pattern Image Note
TS23: lymphatic system Present Regionally restricted S2F
TS23: skin Present Regionally restricted S2F
Specimen S2G: embryonic day 15.5; Flt4tm1Ali/Flt4+, Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: red - Vegfr3 (Flt4); green - Prox1 (assay MGI:6507015); blue - Lyve1 (assay MGI:6507020).
Structure Level Pattern Image Note
TS23: lymphatic system Trace Regionally restricted S2G Lymphatic vessels were abnormally shaped or reduced in size and thinner. Authors report complete lack of lymphatic vessels in some double-heterozygous embryos.
TS23: skin Trace Regionally restricted S2G Lymphatic vessels were abnormally shaped or reduced in size and thinner. Authors report complete lack of lymphatic vessels in some double-heterozygous embryos.
Specimen 5A: embryonic day 11.5 (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: cardinal vein Present 5A
Specimen 5A': embryonic day 11.5 (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: cardinal vein Present 5A'
Specimen 5B: embryonic day 11.5; Flt4tm1Ali/Flt4+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: cardinal vein Weak Regionally restricted 5B Expression reduced in lymphatic endothelial cell (LEC) progenitors.
Specimen 5B': embryonic day 11.5; Flt4tm1Ali/Flt4+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: cardinal vein Weak Regionally restricted 5B' Expression reduced in lymphatic endothelial cell (LEC) progenitors.
Specimen 5C: embryonic day 11.5; Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: cardinal vein Weak Regionally restricted 5C Expression reduced in lymphatic endothelial cell (LEC) progenitors.
Specimen 5C': embryonic day 11.5; Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: cardinal vein Weak Regionally restricted 5C' Expression reduced in lymphatic endothelial cell (LEC) progenitors.
Specimen 5D: embryonic day 11.5; Flt4tm1Ali/Flt4+, Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: cardinal vein Trace Regionally restricted 5D Expression further reduced in double heterozygous embryos than in single heterozygous littermates.
Specimen 5D': embryonic day 11.5; Flt4tm1Ali/Flt4+, Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: cardinal vein Trace Regionally restricted 5D' Expression further reduced in double heterozygous embryos than in single heterozygous littermates.
Specimen 5E: embryonic day 11.5 (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Present 5E
Specimen 5E': embryonic day 11.5 (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Present 5E'
Specimen 5F: embryonic day 11.5; Flt4tm1Ali/Flt4+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Weak Regionally restricted 5F Expression reduced in differentiating lymphatic endothelial cells (LECs).
Specimen 5F': embryonic day 11.5; Flt4tm1Ali/Flt4+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Weak Regionally restricted 5F' Expression reduced in differentiating lymphatic endothelial cells (LECs).
Specimen 5G: embryonic day 11.5; Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Weak Regionally restricted 5G Expression reduced in differentiating lymphatic endothelial cells (LECs).
Specimen 5G': embryonic day 11.5; Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Weak Regionally restricted 5G' Expression reduced in differentiating lymphatic endothelial cells (LECs).
Specimen 5H: embryonic day 11.5; Flt4tm1Ali/Flt4+, Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Trace Regionally restricted 5H Expression further reduced in double heterozygous embryos than in single heterozygous littermates.
Specimen 5H': embryonic day 11.5; Flt4tm1Ali/Flt4+, Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Vegfr3 (Flt4); red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Trace Regionally restricted 5H' Expression further reduced in double heterozygous embryos than in single heterozygous littermates.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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