Tg(IGH,IGKV@)HC2KCo4Nlo
Transgene Detail
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| Symbol: |
Tg(IGH,IGKV@)HC2KCo4Nlo |
| Name: |
transgene insertion HC2KCo4, Nils Lonberg |
| MGI ID: |
MGI:6505567 |
| Synonyms: |
HC2/KCo4/JHD/JCkappaD |
| Transgene: |
Tg(IGH,IGKV@)HC2KCo4Nlo Location: unknown
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| Alliance: |
Tg(IGH,IGKV@)HC2KCo4Nlo page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(IGH,IGKV@)HC2KCo4Nlo expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| human |
IGH (3492) |
expresses human IGHV5-51, 3-30-3, 1-69 and 4-34 variable segments plus D, J and C segments |
| human |
IGKV@ (3519) |
expresses a selection of human IKGV segments |
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Mutation details: The transgene contains the human immunoglobulin heavy variable 5-51, 3-30-3, 1-69 and 4-34 gene segments and part of the human immunoglobulin kappa locus. The IGHV segments also include sixteen D segments, all six J segments, and immunoglobulin heavy constant mu (IGHM) and gamma 1 (IGHG1) (all contained in the in the HC2 minilocus). The IGKV segments are contained in the KCo4 minilocus, which comprises IGK segments (IGKV3D-11, IGKV3-20, IGKV1D-16, IGKV3-11) and IGKJ and IGKC enhancer sequences from plasmids pKV4 and pKC1B.
(J:301297)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:301297 Fishwild DM, et al., High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice. Nat Biotechnol. 1996 Jul;14(7):845-51 |
| All: |
1 reference(s) |
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Analysis Tools
