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Gene Expression Data
Assay Details
Assay
Reference: J:165470 Hallock PT, et al., Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L. Genes Dev. 2010 Nov 1;24(21):2451-61
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6502134
Gene symbol: Syn2
Gene name: synapsin II
Results
Specimen 7A Crkf/f; Crk-Lf/f: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Note: Also stained for Syn1 (assay MGI:6502132) and Syp (assay MGI:6502130); all green.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 7A Synaptophysin/Synapsin Crkf/f; Crk-Lf/f Expression at synapses.
Specimen 7A Crkf/f; Crk-Lf/f inset: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Note: Double labeled: green - Syn1, Syn2 and Syp (assay MGI:6502130); red - AchR.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 7A Synaptophysin/Synapsin Crkf/f; Crk-Lf/f inset Expression at synapses.
Specimen 7A Crkf/f; Crk-Lf/f; myf5cre: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Myf5tm3(cre)Sor/Myf5+ (more )
Note: Conditional mutant. Also stained for Syn1 (assay MGI:6502132) and Syp (assay MGI:6502130); all green.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 7A Synaptophysin/Synapsin Crkf/f; Crk-Lf/f; myf5cre Authors report fewer synapses than wild type, with synapses broadly distributed in muscle.
Specimen 7A Crkf/f; Crk-Lf/f; myf5cre inset: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Myf5tm3(cre)Sor/Myf5+ (more )
Note: Conditional mutant. Double labeled: green - Syn1, Syn2 and Syp (assay MGI:6502130); red - AchR.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 7A Synaptophysin/Synapsin Crkf/f; Crk-Lf/f; myf5cre inset Authors report fewer synapses than wild type.
Specimen 8A Crkf/f; Crk-Lf/f: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 8A Synapsin Crkf/f; Crk-Lf/f
Specimen 8A Crkf/f; Crk-Lf/f; myf5cre: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Myf5tm3(cre)Sor/Myf5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 8A Synapsin Crkf/f; Crk-Lf/f; myf5cre Authors report synapses were unusually small.
Specimen 8C Crkf/f; Crk-Lf/f: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 8C Crkf/f: Crk-Lf/f
Specimen 8C Crkf/f; Crk-Lf/f; myf5cre: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Myf5tm3(cre)Sor/Myf5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 8C Crkf/f; Crk-Lf/f; myf5cre Motor axons failed to terminate at synapses.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory