Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Or4e5-cre)1Hsak
Name:	transgene insertion 1, Hitoshi Sakano
MGI ID:	MGI:6491953
Synonyms:	H-Cre, Olfr1507Cre, Tg-H-Cre, Tg(Olfr1507-cre)1Hsak
Transgene:	Tg(Or4e5-cre)1Hsak  Location: unknown
Alliance:	Tg(Or4e5-cre)1Hsak page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Or4e5-cre)1Hsak expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Or4e5 (MGI:3031341)   Mutation details: Cre recombinase gene is expressed under the control of upstream cis-acting DNA region of the mouse Olfr1507, 2-kb conserved homology region, mouse H element enhancer, which regulates odorant receptor (OR) gene cluster expression and Olfr1507 promoter. Due to the H enhancer activity, the Cre gene, now under the control of the Tg MOR28 promoter, is frequently chosen and activated for transcription in OSNs. The MOR28 promoter cannot be activated when any one of the endogenous OR genes is expressed first, due to OR-mediated negative feedback regulation. (J:167943)

Activity:	Tissue activity of this recombinase allele
Driver:	Or4e5 (mouse) Summary of all recombinase alleles driven by Or4e5. Comparative matrix view of recombinase activities Alliance mouse Or4e5 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:167943 Takeuchi H, et al., Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb. Cell. 2010 Jun 11;141(6):1056-67
All:	2 reference(s)