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Gene Expression Data
Assay Details
Assay
Reference: J:289397 Kowalkowski A, et al., Lack of discreet colocalization of epithelial apoptosis to the atretic precursor in the colon of the Fibroblast growth factor receptor 2IIIb mouse and staining consistent with cellular movement suggest a revised model of atresia formation. Dev Dyn. 2020 Jun;249(6):741-753
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6491430
Gene symbol: Cdh1
Gene name: cadherin 1
Antibody: Anti-E-Cadherin (610181; Clone 36)
Detection system: horseradish peroxidase
Assay notes: Fgfr2IIIb-/- (null) embryos were generated by mating Fgfr2IIIbflox/+; HprtCre/+ females with Fgfr2IIIbflox/flox males. Fgfr2IIIbflox/flox (control) embryos were generated within the same litters without the HPRT-Cre allele. Two antibodies were described, but the one used in this assay was not detailed. Antibody name MGI:5002350 may have been used in this assay.
Results
Specimen 6A: embryonic day 11.5; Fgfr2tm1Dsn/Fgfr2tm1Dsn (more )
Structure Level Pattern Image Note
TS19: large intestine Present Regionally restricted 6A Expression in distal colon. Discrete expression along plasma membrane of pseudostratified columnar epithelium.
Specimen 6B: embryonic day 11.5; Fgfr2tm1Dsn/Fgfr2tm1Dsn (more )
Structure Level Pattern Image Note
TS19: large intestine Present Regionally restricted 6B Expression in distal colon. Discrete expression along plasma membrane of pseudostratified columnar epithelium.
Specimen 6C: embryonic day 11.5; Fgfr2tm1Dsn/Fgfr2tm1Dsn (more )
Structure Level Pattern Image Note
TS19: large intestine Present Regionally restricted 6C Expression in distal colon. Discrete expression along plasma membrane of pseudostratified columnar epithelium.
Specimen 6D: embryonic day 11.5; Fgfr2tm1Dsn/Fgfr2tm1Dsn, Hprt1tm1(CAG-cre)Mnn/Hprt1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: large intestine Present Diffuse 6D Expression in distal colon. Diffuse pattern of expression. Authors report lack of pseudostratified columnar architecture with a loss of lumen.
Specimen 6E: embryonic day 11.5; Fgfr2tm1Dsn/Fgfr2tm1Dsn, Hprt1tm1(CAG-cre)Mnn/Hprt1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: intestine epithelium Present Diffuse 6E Expression in distal colon. Increased expression within cytoplam of epithelial cells.
TS19: intestine mesenchyme Weak Single cells 6E Rare expressing cells in colon mesenchyme.
Specimen 6F: embryonic day 11.5; Fgfr2tm1Dsn/Fgfr2tm1Dsn, Hprt1tm1(CAG-cre)Mnn/Hprt1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: intestine epithelium Trace 6F Expression in distal colon. Greatly diminished expression. Authors report lack of pseudostratified columnar architecture with a loss of lumen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory