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Gene Expression Data
Assay Details
Assay
Reference: J:62599 Vialard F, et al., Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study. Brain Res Dev Brain Res. 2000 May 11;121(1):73-8
Assay type: RNA in situ
MGI Accession ID: MGI:6479668
Gene symbol: Sim2
Gene name: single-minded family bHLH transcription factor 2
Probe: Sim2 cDNA7
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1c: embryonic day 12.5; Ts(16C-tel)1Cje/0 (more )
Structure Level Pattern Image Note
TS20: prosomere 2 Present Regionally restricted 1c Expression is at the boundary between prosomeres P2 and and P3.
TS20: prosomere 3 Present Regionally restricted 1c Expression is at the boundary between prosomeres P2 and and P3.
TS20: diencephalon Present Regionally restricted 1c Expression is at the base.
TS20: chondrocranium Present Regionally restricted 1c Expression is at the basio-occipital anlage.
TS20: limb Present Regionally restricted 1c Expression is in the dorso-caudal part of the limbs.
TS20: C1 vertebral cartilage condensation Present 1c
TS20: primary palate Present 1c
TS20: rib pre-cartilage condensation Present 1c
TS20: vertebral cartilage condensation Present 1c
Specimen 1d: embryonic day 12.5; Ts(16C-tel)1Cje/0 (more )
Note: Hemisected fetus.
Structure Level Pattern Image Note
TS20: prosomere 2 Present Regionally restricted 1d Expression is at the boundary between prosomeres P2 and and P3.
TS20: prosomere 3 Present Regionally restricted 1d Expression is at the boundary between prosomeres P2 and and P3.
TS20: diencephalon Present Regionally restricted 1d Expression is at the base.
TS20: chondrocranium Present Regionally restricted 1d Expression is at the basio-occipital anlage.
TS20: limb Present Regionally restricted 1d Expression is in the dorso-caudal part of the limbs.
TS20: C1 vertebral cartilage condensation Present 1d
TS20: primary palate Present 1d
TS20: rib pre-cartilage condensation Present 1d
TS20: thyroglossal duct Present 1d
TS20: vertebral cartilage condensation Present 1d
Specimen 3b1: embryonic day 12.5; Ts(16C-tel)1Cje/0 (more )
Note: Hemisected fetus.
Structure Level Pattern Image Note
TS20: zona limitans intrathalamica Strong Regionally restricted 3b1 There was a close to 1.5-fold increase in expression compared to control mice.
Specimen 3b2: embryonic day 12.5 (more )
Note: Hemisected fetus.
Structure Level Pattern Image Note
TS20: zona limitans intrathalamica Present Regionally restricted 3b2 Expression is at the base.
Specimen not shown E11.5: embryonic day 11.5; Ts(16C-tel)1Cje/0 (more )
Structure Level Pattern Image Note
TS19: embryo Present
Specimen not shown E13: embryonic day 13.0; Ts(16C-tel)1Cje/0 (more )
Structure Level Pattern Image Note
TS21: embryo Present
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory