H2ax Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:261042 Welcker D, et al., AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene. 2018 Mar;37(11):1503-1518
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6477300
Gene symbol:	H2ax
Gene name:	H2A.X variant histone

Antibody:	anti-phospho-histone H2A.X (Ser139) (CST;#2577)
Detection system:	Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase

Results

Specimen 1d E16.5 Skin: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: skin	Present	Regionally restricted	1d Skin gamma-H2AX	Proliferating cells were noted juxtaposed to the basal membrane.

Specimen 1d E16.5 Liver: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: liver	Present		1d Liver gamma-H2AX

Specimen 1e Adult Bone marrow: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: bone marrow	Present		1e Bone marrow gamma-H2AX

Specimen 1e Adult Small intestine: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: small intestine	Strong	Regionally restricted	1e Small intestine gamma-H2AX	The proliferative compartment in the small intestine, confined to the bottom of the crypts, was stained strongly.

Specimen S1: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: heart	Ambiguous		S1_Heart gamma-H2AX	Heart acted as a post-mitotic control.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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