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Gene Expression Data
Assay Details
Assay
Reference: J:236232 Wang W, et al., Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct;12(10):e1006352
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6473217
Gene symbol: Ski
Gene name: ski sarcoma viral oncogene homolog (avian)
Antibody: Anti-Ski (H329; sc-9140)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 6D Smad2fx/fx: embryonic day 18.5; Smad2tm2Rob/Smad2tm2Rob (more )
Structure Level Pattern Image Note
TS26: tibia Present Regionally restricted 6D Smad2fx/fx Expression was detected in the nucleus in prehypertrophic and hypertrophic zones.
Specimen 6D Smad2cko: embryonic day 18.5; Smad2tm2Rob/Smad2tm2Rob, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: tibia Present Regionally restricted 6D Smad2cko There was no obvious change in Ski expression levels in prehypertrophic and hypertrophic chondrocytes in the mutant compared with control.
Specimen 6D Smad3-/-: embryonic day 18.5; Smad3tm1Par/Smad3tm1Par (more )
Structure Level Pattern Image Note
TS26: tibia Present Regionally restricted 6D Smad3-/- There was no obvious change in Ski expression levels in prehypertrophic and hypertrophic chondrocytes in the mutant compared with control. However, expression was increased in the proliferative zone.
Specimen 6D Smad2cko;Smad3-/-: embryonic day 18.5; Smad2tm2Rob/Smad2tm2Rob, Smad3tm1Par/Smad3tm1Par, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: tibia Present Regionally restricted 6D Smad2cko;Smad3-/- There was no obvious change in Ski expression levels in prehypertrophic and hypertrophic chondrocytes in the double mutant compared with control. However, expression was increased in the proliferative zone.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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