Gene Expression Data
Assay Details
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Assay
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Reference:
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J:236232
Wang W, et al., Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct;12(10):e1006352
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:6473216
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Gene symbol:
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Skil
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Gene name:
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SKI-like
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Results
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Specimen
6C Smad2:
(close  )
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Genetic Background:
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involves: 129 * C57BL/6J * CD-1 * SJL
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Mutant Allele(s):
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Smad2tm2Rob/Smad2tm2Rob
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Age:
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embryonic day 18.5
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Age Note:
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The text referred to this specimen's age as P0, while the figure legend indicated it was E18.5.
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: tibia |
Present |
Regionally restricted |
6C Smad2fx/fx
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Expression was detected in the nucleus in prehypertrophic and hypertrophic zones.
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Specimen
6C Smad2:
(close )
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Genetic Background:
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involves: 129 * C57BL/6J * CD-1 * SJL
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Mutant Allele(s):
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Smad2tm2Rob/Smad2tm2Rob
Tg(Col2a1-cre)1Bhr/0
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Age:
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embryonic day 18.5
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Age Note:
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The text referred to this specimen's age as P0, while the figure legend indicated it was E18.5.
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Paraffin
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Note:
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Conditional mutant.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: tibia |
Present |
Regionally restricted |
6C Smad2cko
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There was no obvious change in Skil expression levels in prehypertrophic and hypertrophic chondrocytes in the mutant compared with control. However, expression was increased in the proliferative zone.
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Specimen
6C Smad3<-/->:
(close )
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Genetic Background:
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involves: 129 * C57BL/6J * CD-1 * SJL
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Mutant Allele(s):
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Smad3tm1Par/Smad3tm1Par
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Age:
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embryonic day 18.5
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Age Note:
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The text referred to this specimen's age as P0, while the figure legend indicated it was E18.5.
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: tibia |
Present |
Regionally restricted |
6C Smad3-/-
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There was no obvious change in Skil expression levels in prehypertrophic and hypertrophic chondrocytes in the mutant compared with control. However, expression was increased in the proliferative zone.
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Specimen
6C Smad2;Smad3<-/->:
(close )
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Genetic Background:
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involves: 129 * C57BL/6J * CD-1 * SJL
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Mutant Allele(s):
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Smad2tm2Rob/Smad2tm2Rob
Smad3tm1Par/Smad3tm1Par
Tg(Col2a1-cre)1Bhr/0
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Age:
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embryonic day 18.5
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Age Note:
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The text referred to this specimen's age as P0, while the figure legend indicated it was E18.5.
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Paraffin
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Note:
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Conditional mutant.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: tibia |
Present |
Regionally restricted |
6C Smad2cko;Smad3-/-
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There was no obvious change in Skil expression levels in prehypertrophic and hypertrophic chondrocytes in the double mutant compared with control. However, expression was increased in the proliferative zone.
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)
Analysis Tools