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Gene Expression Data
Assay Details
Assay
Reference: J:236232 Wang W, et al., Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct;12(10):e1006352
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6473190
Gene symbol: Pcna
Gene name: proliferating cell nuclear antigen
Antibody: anti-PCNA (D3H8P) Rabbit mAb #13110
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 2B Smad2fx/fx: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob (more )
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 2B Smad2fx/fx Expression was detected in the resting zone of the proximal tibia.
Specimen 2B Smad2cko: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 2B Smad2cko A 2 to 3-fold increase in PCNA-positive cells was seen in the resting zone of Smad2<CKO> mice compared with control.
Specimen 2B Smad3-/-: postnatal day 0; Smad3tm1Par/Smad3tm1Par (more )
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 2B Smad3-/- A 2 to 3-fold increase in PCNA-positive cells was seen in the resting zone of Smad3-/- mice compared with control.
Specimen 2B Smad2cko;Smad3-/-: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob, Smad3tm1Par/Smad3tm1Par, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 2B Smad2cko;Smad3-/- A 2 to 3-fold increase in PCNA-positive cells was seen in the resting zone of Smad2/3 double mutant mice compared with control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
MGI 6.24 		The Jackson Laboratory