Tg(Thy1-CYP19A1)#Lire
Transgene Detail
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| Symbol: |
Tg(Thy1-CYP19A1)#Lire |
| Name: |
transgene insertion, Rena Li |
| MGI ID: |
MGI:6472733 |
| Synonyms: |
Thy1-Ar |
| Transgene: |
Tg(Thy1-CYP19A1)#Lire Location: unknown Genetic Position: ChrUN, Syntenic
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| Alliance: |
Tg(Thy1-CYP19A1)#Lire page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Thy1-CYP19A1)#Lire expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CYP19A1 (1588) |
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mouse promoter, human gene |
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Mutation details: The vector contains the entire mouse thymus cell antigen 1 theta gene (including the essential promoter and neuron-specific upstream regulatory sequences, 3' polyA signal sequences and neuronal-specific expression signal containing introns) with the coding region removed (from the ATG in exon 2 to the end in exon 4, including intervening introns 2 and 3). The human cytochrome P450 family 19 subfamily A member 1 gene was inserted in the place of the coding sequence. The transgene expresses the inserted gene in neuronal cells and not in non-neuronal cells) in the nervous system.
(J:296884)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:296884 Ma L, et al., Brain estrogen alters the effects of the antidepressant sertraline in middle-aged female and male mice. Mol Cell Endocrinol. 2020 Oct 1;516:110947 |
| All: |
2 reference(s) |
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Analysis Tools
