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Gene Expression Data
Assay Details
Assay
Reference: J:176603 Patel N, et al., Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev Biol. 2011 Oct 1;358(1):156-67
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6472700
Gene symbol: Axin2
Gene name: axin 2
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 12.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS20: oral region mesenchyme Present Regionally restricted 1A Expression in mesenchyme adjacent to oral epithelium as well as in salivary gland condensed mesenchyme facing tip of epithelial bud of submandibular gland, on lingual side of gland.

Specimen 1B: embryonic day 13.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS21: submandibular gland primordium mesenchyme Present Regionally restricted 1B Expression restricted to salivary gland condensed mesenchyme. Expression in mesenchyme facing the submandibular gland and surrounding submandibular gland
TS21: sublingual gland primordium mesenchyme Present Regionally restricted 1B Expression in mesenchyme surrounding sublingual gland main ducts. No expression in mesenchyme facing the sublingual gland.

Specimen 1C: embryonic day 13.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS21: salivary gland epithelium Absent 1C No expression in salivary gland epithelial structures.

Specimen 1D: embryonic day 14.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS22: submandibular gland primordium mesenchyme Present Regionally restricted 1D Expression in mesenchyme facing submandibular gland.
TS22: sublingual gland primordium mesenchyme Present Regionally restricted 1D Strong expression in the mesenchyme surrounding the main duct of the sublingual gland. No expression in mesenchyme facing the sublingual gland.
TS22: sublingual gland primordium epithelium Present 1D Expression also present in epithelium.
TS22: submandibular gland primordium epithelium Present 1D Expression also present in epithelium.

Specimen 1E: embryonic day 14.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS22: sublingual gland primordium mesenchyme Strong Regionally restricted 1E Strong expression in mesenchyme surrounding main duct of sublingual gland.
TS22: submandibular gland primordium mesenchyme Weak Regionally restricted 1E Expression downregulated in mesenchyme surrounding submandibular gland main duct.
TS22: submandibular gland primordium epithelium Strong Regionally restricted 1E Expression up-regulated in epithelium of submandibular gland main duct.

Specimen 1F: embryonic day 14.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS22: sublingual gland primordium mesenchyme Weak Regionally restricted 1F Expression dowregulated in mesenchyme surrounding sublingual gland main duct.
TS22: sublingual gland primordium epithelium Strong Regionally restricted 1F Expression up-regulated in epithelium of sublingual main duct.

Specimen 1G: embryonic day 15.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS23: salivary gland epithelium Present Regionally restricted 1G Expression in epithelium spread from main ducts to smaller duct. Nascent lumina lined by epithelial cells were devoid of expression.

Specimen 1H: embryonic day 18.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS26: sublingual gland Strong Regionally restricted 1H Strong expression throughout ducts of both glands. No expression in acini.
TS26: submandibular gland Strong Regionally restricted 1H Strong expression throughout ducts of both glands. No expression in acini.

Specimen 1I: embryonic day 18.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS26: salivary gland Strong Regionally restricted 1I Strong expression throughout ducts of both glands. No expression in acini.

Specimen 1J: embryonic day 18.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS26: salivary gland Strong Regionally restricted 1J Strong expression throughout ducts of both glands. No expression in acini.

Specimen 1K: embryonic day 18.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS26: salivary gland Present Regionally restricted 1K Some intercalated duct visibly devoid of expression.

Specimen 1L: embryonic day 18.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS26: salivary gland mesenchyme Present Regionally restricted 1L Expression in mesenchyme surrounding ducts, including flat cells lining walls of ducts as well as loose mesenchyme at periphery.

Specimen 1M: embryonic day 18.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS26: salivary gland mesenchyme Present Regionally restricted 1M Expression in mesenchyme surrounding ducts, including flat cells lining walls of ducts as well as loose mesenchyme at periphery.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory