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Gene Expression Data
Assay Details
Assay
Reference: J:173123 Mahoney Rogers AA, et al., Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling. Dev Biol. 2011 May 1;353(1):94-104
Assay type: RNA in situ
MGI Accession ID: MGI:6471926
Gene symbol: Wnt8a
Gene name: wingless-type MMTV integration site family, member 8A
Probe: Wnt8a probe4
Probe preparation: labelled with digoxigenin RNA
Results
Specimen 5A: embryonic day 8.0; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 6 somite stage.
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 5A Expression in rhombomere 4.
Specimen 5B: embryonic day 8.0; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 6 somite stage.
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 5B Expression domain larger and more intense compared to control.
Specimen 5I: embryonic day 8.0; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 7 somite stage.
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 5I Expression in rhombomere 4.
Specimen 5J: embryonic day 8.0; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 6 somite stage.
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 5J Expression dramatically expanded in double mutant compared to control.
Specimen 5K: embryonic day 8.0; Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 7 somite stage.
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 5K Expression in rhombomere 4. No increase in expression in single mutant.
Specimen 6E: embryonic day 8.0; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 6 somite stage.
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 6E Expression in rhombomere 4.
Specimen not shown: embryonic day 8.0; Fgf10tm1Wss/Fgf10+, Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted Expression in rhombomere 4. Expression indistisguishable compared to control.
Specimen 6F: embryonic day 8.0; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 7 somite stage.
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 6F Expression in rhombomere 4. Expression domain expanded compared to control.
Specimen 6G: embryonic day 8.0; Fgf10tm1Wss/Fgf10+, Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 6 somite stage.
Structure Level Pattern Image Note
TS12: rhombomere Present Regionally restricted 6G Expression in rhombomere 4. Size of expression domain more similar to double and triple heterozygotes.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory