Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Sox17em1.1(phiC31*)Okn
Name:	SRY (sex determining region Y)-box 17; endonuclease-mediated mutation 1.1, Hideyuki Okano
MGI ID:	MGI:6471921
Synonyms:	Sox172A-phiC31odeltaPuro
Gene:	Sox17  Location: Chr1:4561154-4567577 bp, - strand  Genetic Position: Chr1, 1.65 cM
Alliance:	Sox17em1.1(phiC31*)Okn page

Germline Transmission:	Earliest citation of germline transmission: J:284134
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NCrlCrlj

Allele Type:    Endonuclease-mediated (Recombinase) Mutation:    Insertion   Sox17em1.1(phiC31*)Okn expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Sox17 (MGI:107543)   Mutation details: CRISPR-targeting introduced at the end of the coding sequence in exon 5 a GSG (Gly-Ser-Gly)-linker, porcine teschovirus-1 2A (P2A) peptide, SV40 virus NLS, phiC31o integrase gene, and puromycin resistance cassette flanked by FRT sites (FRT/F3/F5). Flp-mediated recombination removed the selection cassette. (J:284134)

Activity:	Tissue activity of this recombinase allele
Driver:	Sox17 (mouse) Summary of all recombinase alleles driven by Sox17. Alliance mouse Sox17 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox17 Mutation:	28 strains or lines available

Original:	J:284134 Serizawa T, et al., Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers. Development. 2019 Nov 4;146(21):dev174938
All:	1 reference(s)