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Gene Expression Data
Assay Details
Assay
Reference: J:173123 Mahoney Rogers AA, et al., Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling. Dev Biol. 2011 May 1;353(1):94-104
Assay type: RNA in situ
MGI Accession ID: MGI:6471916
Gene symbol: Pax8
Gene name: paired box 8
Probe: Pax8 probe7
Probe preparation: labelled with digoxigenin RNA
Results
Specimen 0-2 somite stage control not shown: embryonic day 8.0; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Structure Level Pattern Image Note
TS12: otic pre-placode Present
Specimen 0-2 somite stage Spry1-/-;Spry2-/- not shown: embryonic day 8.0; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Structure Level Pattern Image Note
TS12: otic pre-placode Present Expression indistinguishable from control embryos.
Specimen 1A: embryonic day 8.0; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 4 somite stage.
Structure Level Pattern Image Note
TS12: otic pre-placode Present 1A
Specimen 1B: embryonic day 8.0; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 4 somite stage.
Structure Level Pattern Image Note
TS12: otic pre-placode Present 1B No signficant difference in size or intensity of expression domain compared to control.
Specimen 1G: embryonic day 8.5; Spry1tm1.1Jdli/Spry1+, Spry2tm1.1Mrt/Spry2+ (more )
Note: 10 somite stage.
Structure Level Pattern Image Note
TS13: otic placode Present 1G
Specimen 1H: embryonic day 8.5; Spry1tm1.1Jdli/Spry1tm1.1Jdli, Spry2tm1.1Mrt/Spry2tm1.1Mrt (more )
Note: 10 somite stage.
Structure Level Pattern Image Note
TS13: otic placode Present Regionally restricted 1H Expression domain expanded in all directions compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory