Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Sox1em1(cre)Okn
Name:	SRY (sex determining region Y)-box 1; endonuclease-mediated mutation 1, Hideyuki Okano
MGI ID:	MGI:6471911
Synonyms:	Sox12A-Cre
Gene:	Sox1  Location: Chr8:12445519-12449555 bp, + strand  Genetic Position: Chr8, 5.73 cM, cytoband A1-A2
Alliance:	Sox1em1(cre)Okn page

Germline Transmission:	Earliest citation of germline transmission: J:284134
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NCrlCrlj

Allele Type:    Endonuclease-mediated (Recombinase) Mutation:    Insertion   Sox1em1(cre)Okn expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Sox1 (MGI:98357)   Mutation details: CRISPR-targeting introduced at the end of the coding sequence in exon 1 a GSG (Gly-Ser-Gly)-linker, porcine teschovirus-1 2A (P2A) peptide, SV40 virus NLS, bacteriophage P1 cre recombinase gene, and puromycin resistance cassette flanked by FRT sites (FRT/F3/F5). (J:284134)

Activity:	Tissue activity of this recombinase allele
Driver:	Sox1 (mouse) Summary of all recombinase alleles driven by Sox1. Alliance mouse Sox1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sox1 Mutation:	13 strains or lines available

Original:	J:284134 Serizawa T, et al., Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers. Development. 2019 Nov 4;146(21):dev174938
All:	2 reference(s)