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Gene Expression Data
Assay Details
Assay
Reference: J:160476 Ge C, et al., Effects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes. BMC Dev Biol. 2010;10:36
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6468500
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: anti-Pecam1
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 4A: embryonic day 9.5; Notch1tm2Pst/Notch1+ (more )
Note: 23-26 somites
Structure Level Pattern Image Note
TS15: anterior cardinal vein Present 4A
TS15: blood vessel Present 4A Expression is seen in endothelial cells.
Specimen 4B: embryonic day 9.5; Notch1tm2Pst/Notch1tm2Pst (more )
Note: 23-26 somites
Structure Level Pattern Image Note
TS15: anterior cardinal vein Present 4B The morphology of the anterior cardinal vein is comparable to wild type in this mutant.
TS15: blood vessel Present 4B Expression is seen in endothelial cells.
Specimen 4C: embryonic day 9.5; Notch1tm2Pst/Notch1tm2.1Pst (more )
Note: 17-21 somites
Structure Level Pattern Image Note
TS15: anterior cardinal vein Present 4C The morphology of the anterior cardinal vein is defective in this mutant.
TS15: blood vessel Present 4C Expression is seen in endothelial cells.
Specimen 4D: embryonic day 9.5; Notch1tm2Pst/Notch1tm2.1Pst (more )
Note: 13-17 somites
Structure Level Pattern Image Note
TS15: anterior cardinal vein Present 4D The morphology of the anterior cardinal vein is defective in this mutant.
TS15: blood vessel Present 4D Expression is seen in endothelial cells.
Specimen 4E: embryonic day 9.5; Notch1tm2Pst/Notch1+ (more )
Note: 23-26 somites
Structure Level Pattern Image Note
TS15: head blood vessel Present 4E
Specimen 4F: embryonic day 9.5; Notch1tm2Pst/Notch1tm2Pst (more )
Note: 23-26 somites
Structure Level Pattern Image Note
TS15: head blood vessel Present 4F Vascular remodeling in the brain is comparable to wild type in this mutant.
Specimen 4G: embryonic day 9.5; Notch1tm2Pst/Notch1tm2.1Pst (more )
Note: 17-21 somites
Structure Level Pattern Image Note
TS15: head blood vessel Present 4G Vascular remodeling in the brain is defective in this mutant.
Specimen 4H: embryonic day 9.5; Notch1tm2Pst/Notch1tm2.1Pst (more )
Note: 13-17 somites
Structure Level Pattern Image Note
TS15: head blood vessel Present 4H Vascular remodeling in the brain is severely defective in this mutant.
Specimen 4I: embryonic day 9.5; Notch1tm2Pst/Notch1+ (more )
Note: 23-26 somites
Structure Level Pattern Image Note
TS15: heart Present 4I
Specimen 4J: embryonic day 9.5; Notch1tm2Pst/Notch1tm2Pst (more )
Note: 23-26 somites
Structure Level Pattern Image Note
TS15: heart Present 4J Vascular remodeling in the heart is comparable to wild type in this mutant.
Specimen 4K: embryonic day 9.5; Notch1tm2Pst/Notch1tm2.1Pst (more )
Note: 17-21 somites
Structure Level Pattern Image Note
TS15: heart Present 4K Vascular remodeling in the heart is defective in this mutant. Blood leakage from the heart is noted.
Specimen 4L: embryonic day 9.5; Notch1tm2Pst/Notch1tm2.1Pst (more )
Note: 13-17 somites
Structure Level Pattern Image Note
TS15: heart Present 4L Vascular remodeling in the heart is severely defective in this mutant.
Specimen 4M: embryonic day 9.5; Notch1tm2Pst/Notch1+ (more )
Note: 23-26 somites
Structure Level Pattern Image Note
TS15: intersomitic blood vessel Present 4M
Specimen 4N: embryonic day 9.5; Notch1tm2Pst/Notch1tm2Pst (more )
Note: 23-26 somites
Structure Level Pattern Image Note
TS15: intersomitic blood vessel Present 4N The organization of the intersomitic vessels is comparable to wild type in this mutant.
Specimen 4O: embryonic day 9.5; Notch1tm2Pst/Notch1tm2.1Pst (more )
Note: 17-21 somites
Structure Level Pattern Image Note
TS15: intersomitic blood vessel Present 4O The intersomitic vessels are mildly disorganized in this mutant.
Specimen 4P: embryonic day 9.5; Notch1tm2Pst/Notch1tm2.1Pst (more )
Note: 13-17 somites
Structure Level Pattern Image Note
TS15: intersomitic blood vessel Absent 4P The intersomitic vessels are essentially absent in this mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
MGI 6.24 		The Jackson Laboratory