Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Pdgfratm2(cre/ERT2,-EGFP)Msas
Name:	platelet derived growth factor receptor, alpha polypeptide; targeted mutation 2, Masakiyo Sasahara
MGI ID:	MGI:6467930
Synonyms:	Pdgfra-CreERT2-Egfp, PR
Gene:	Pdgfra  Location: Chr5:75312953-75358876 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance:	Pdgfratm2(cre/ERT2,-EGFP)Msas page

Germline Transmission:	Earliest citation of germline transmission: J:250501
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Pdgfratm2(cre/ERT2,-EGFP)Msas expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Pdgfra (MGI:97530)   Mutation details: The Pdgfra promoter region drives expression of cre recombinase gene and enhanced green fluorescent protein (Egfp) gene. Cre is inserted after the promoter alelments and an internal ribosome entry site (IRES) sequence and EGFP sequence follows. (J:250501)

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfra (mouse) Summary of all recombinase alleles driven by Pdgfra. Alliance mouse Pdgfra gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfra Mutation:	85 strains or lines available

Original:	J:250501 Horikawa S, et al., PDGFRalpha plays a crucial role in connective tissue remodeling. Sci Rep. 2015 Dec 7;5:17948
All:	3 reference(s)