Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Smoc2tm1(cre/ERT2)Cle
Name:	SPARC related modular calcium binding 2; targeted mutation 1, Hans Clevers
MGI ID:	MGI:6467827
Synonyms:	Smoc2-EGFP-ires-CreERT2
Gene:	Smoc2  Location: Chr17:14499768-14625052 bp, + strand  Genetic Position: Chr17, 8.95 cM, cytoband A2
Alliance:	Smoc2tm1(cre/ERT2)Cle page

Germline Transmission:	Earliest citation of germline transmission: J:186432
Parent Cell Line:	IB10/E14IB10 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Smoc2tm1(cre/ERT2)Cle expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Smoc2 (MGI:1929881)   Mutation details: An EGFP-IRES-creERT2 cassette was inserted at the translational start site of the gene along with a loxP-flanked neomycin cassette. The neomycin gene was then excised in vivo by crossing with a cre-deleter strain. EGFP expression is driven by the endogenous promoter. Cre expression is induced in Smoc2 expressing cells by tamoxifen treatment. (J:186432)

Activity:	Tissue activity of this recombinase allele
Driver:	Smoc2 (mouse) Summary of all recombinase alleles driven by Smoc2. Comparative matrix view of recombinase activities Alliance mouse Smoc2 gene page

In Mice Carrying this Mutation:

8 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smoc2 Mutation:	20 strains or lines available

Original:	J:186432 Munoz J, et al., The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J. 2012;31(14):3079-91
All:	2 reference(s)