About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:235516 Wehner AB, et al., Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons. Development. 2016 May 1;143(9):1560-70
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6467267
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175) (#9661)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6A +/+: postnatal day 0 (more )
Note: Summarized in Fig. 6B.
Structure Level Pattern Image Note
TS27: superior cervical ganglion Present 6A +/+ lower , 6A +/+ upper
Specimen 6A -/-: postnatal day 0; Plxna3tm1Matl/Plxna3tm1Matl (more )
Note: Summarized in Fig. 6B.
Structure Level Pattern Image Note
TS27: superior cervical ganglion Present 6A -/- lower , 6A -/- upper Decreased number of apoptotic neurons, compared with the wild-type.
Specimen not shown +/+: embryonic day 18.5 (more )
Note: Summarized in Fig. 6B.
Structure Level Pattern Image Note
TS26: superior cervical ganglion Present
Specimen not shown -/-: embryonic day 18.5; Plxna3tm1Matl/Plxna3tm1Matl (more )
Note: Summarized in Fig. 6B.
Structure Level Pattern Image Note
TS26: superior cervical ganglion Present Decreased number of apoptotic neurons, compared with the wild-type.
Specimen not shown +/+: postnatal day 20 (more )
Note: Summarized in Fig. 6B.
Structure Level Pattern Image Note
TS28: superior cervical ganglion Present
Specimen not shown -/-: postnatal day 20; Plxna3tm1Matl/Plxna3tm1Matl (more )
Note: Summarized in Fig. 6B.
Structure Level Pattern Image Note
TS28: superior cervical ganglion Present Similar as in the wild-type.
Specimen not shown f/f: postnatal day 1-2; Nrp1tm2Ddg/Nrp1tm2Ddg (more )
Note: Summarized in Fig. 7B.
Structure Level Pattern Image Note
TS27: superior cervical ganglion Present
Specimen not shown cKO: postnatal day 1-2; Nrp1tm2Ddg/Nrp1tm2Ddg, Tg(Syn1-cre)671Jxm/0 (more )
Note: Conditional mutant. Summarized in Fig. 7B.
Structure Level Pattern Image Note
TS27: superior cervical ganglion Present Decreased number of apoptotic neurons, compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory