Tg(Myh6-Sgk1*K141M)1Anr
Transgene Detail
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| Symbol: |
Tg(Myh6-Sgk1*K141M)1Anr |
| Name: |
transgene insertion 1, Anthony Rosenzweig |
| MGI ID: |
MGI:6456549 |
| Synonyms: |
SGK1-KD, Tg(Myh6-Sgk1*K127M)1Anr |
| Transgene: |
Tg(Myh6-Sgk1*K141M)1Anr Location: unknown
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| Alliance: |
Tg(Myh6-Sgk1*K141M)1Anr page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Epitope tag, Inserted expressed sequence) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Tg(Myh6-Sgk1*K141M)1Anr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Sgk1 (MGI:1340062) |
modified mouse gene (K141M) |
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Mutation details: The transgenic construct contains a hemagluttinin (HA) tagged mutant mouse Sgk1 sequence under the control of the cardiac-specific Myh6 promoter. The KD mutation replaces a lysine at residue 141 (published as 127) for a methionine (K141M), inactivating the kinase (kinase dead - KD).
(J:210069)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:210069 Das S, et al., Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation. 2012 Oct 30;126(18):2208-19 |
| All: |
2 reference(s) |
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Analysis Tools
