L1cam Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:37095 Orioli D, et al., Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 1996 15;15(22):6035-49
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6455066
Gene symbol:	L1cam
Gene name:	L1 cell adhesion molecule

Antibody:	anti-L1
Detection system:	Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase

Results

Specimen 3A: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: corpus callosum	Present		3A

Specimen 3B: postnatal day 0; Ephb2^tm1Paw/Ephb2^tm1Paw, Ephb3^tm1Kln/Ephb3^tm1Kln (more

)

Structure	Level	Pattern	Image	Note
TS27: intercerebral commissure	Present	Regionally restricted	3B	Expressed in Probst's bundles. No fibres were crossing the midline.

Specimen 5A: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: anterior commissure	Present		5A

Specimen 5B: postnatal day 0; Ephb2^tm1Paw/Ephb2^tm1Paw, Ephb3^tm1Kln/Ephb3^tm1Kln (more

)

Structure	Level	Pattern	Image	Note
TS27: anterior commissure	Present	Regionally restricted	5B	Aberrantly guided anterior commissure (pars posterior) axons in an abnormal ventral path were seen.

Specimen 5G: postnatal day 0 (more

)

Structure	Level	Image
TS27: anterior commissure	Present	5G
TS27: cerebral internal capsule	Present	5G
TS27: hippocampus	Present	5G

Specimen 5H: postnatal day 0; Ephb2^tm1Paw/Ephb2^tm1Paw, Ephb3^tm1Kln/Ephb3^tm1Kln (more

)

Structure	Level	Image	Note
TS27: cerebral internal capsule	Present	5H
TS27: hippocampus	Present	5H
TS27: anterior commissure	Present	5H	Aberrantly guided anterior commissure (pars posterior) axons in an abnormal ventral path were seen.

Specimen 6C: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: brain commissure	Present	Regionally restricted	6C	Expressed in the habenular and posterior commissure.

Specimen 6D: postnatal day 0; Ephb2^tm1Paw/Ephb2^tm1Paw, Ephb3^tm1Kln/Ephb3^tm1Kln (more

)

Structure	Level	Pattern	Image	Note
TS27: brain commissure	Present	Regionally restricted	6D	Habenular commissural axons failed to traverse the midline and were deflected to grow along the anterior/posterior axis. No guidance defect was observed in posterior commissure axons.

Specimen not shown: postnatal day 0; Ephb3^tm1Kln/Ephb3^tm1Kln (more

)

Structure	Level	Pattern	Image	Note
TS27: anterior commissure	Present			Normal axon bundles identical to wild-type mice.

Specimen not shown: postnatal day 0; Ephb2^tm1Paw/Ephb2⁺, Ephb3^tm1Kln/Ephb3^tm1Kln (more

)

Structure	Level	Pattern	Image	Note
TS27: anterior commissure	Present			Normal axon bundles identical to wild-type mice.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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