Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tmprss12em4Osb
Name:	transmembrane (C-terminal) protease, serine 12; endonuclease-mediated mutation 4, Research Institute for Microbial Diseases, Osaka University
MGI ID:	MGI:6455010
Synonyms:	Tmprss12-8,-7871+5, Tmprss12del
Gene:	Tmprss12  Location: Chr15:100178743-100190943 bp, + strand  Genetic Position: Chr15, 56.24 cM
Alliance:	Tmprss12em4Osb page

Strain of Origin:

(C57BL/6J x DBA/2J)F2

Allele Type:    Endonuclease-mediated (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: CRISPR-targeting of exon 2 deleted 8 bp within the intron with the indel -7871 bp, +5 bp between intron 2 and exon 5 to produce a frameshift mutation with a premature stop codon at the 70th amino acid. Western blot analysis confirmed the absence of protein expression in testicular giant cells and spermatozoa. (J:293874)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tmprss12 Mutation:	30 strains or lines available

Original:	J:293874 Larasati T, et al., Tmprss12 is required for sperm motility and uterotubal junction migration in mice. Biol Reprod. 2020 Aug 4;103(2):254-263
All:	1 reference(s)