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Gene Expression Data
Assay Details
Assay
Reference: J:33050 Sheng HZ, et al., Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science. 1996 May 17;272(5264):1004-7
Assay type: RNA in situ
MGI Accession ID: MGI:6454340
Gene symbol: Pomc
Gene name: pro-opiomelanocortin-alpha
Probe: Pomc probe1
Probe preparation: Antisense labelled with P33 RNA
Results
Specimen 3h +/+: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: remnant of Rathke's pouch Absent 3h +/+
TS20: diencephalon floor plate Present 3h +/+
Specimen 3h -/-: embryonic day 12.5; Lhx3tm1Lmgd/Lhx3tm1Lmgd (more )
Structure Level Pattern Image Note
TS20: remnant of Rathke's pouch Absent 3h -/-
TS20: diencephalon floor plate Present 3h -/-
Specimen 3i +/+: embryonic day 15.5 (more )
Note: 3j is a higher magnification.
Structure Level Pattern Image Note
TS23: adenohypophysis pars anterior Strong 3i +/+ , 3j +/+ Strong expression appears in numerous cells in both the anterior and intermediate lobes of the pituitary.
TS23: adenohypophysis pars intermedia Strong 3i +/+ , 3j +/+ Strong expression appears in numerous cells in both the anterior and intermediate lobes of the pituitary.
Specimen 3i -/-: embryonic day 15.5; Lhx3tm1Lmgd/Lhx3tm1Lmgd (more )
Note: 3j is a higher magnification.
Structure Level Pattern Image Note
TS23: remnant of Rathke's pouch Present Regionally restricted 3j -/- , 3i -/- Only a few positive cells were seen in the ventral base of the pouch remnant in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory