Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1.1(HIFA/cre/ERT2)Yunz
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Zhong Yun
MGI ID:	MGI:6452621
Synonyms:	R26-O2CreER
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1.1(HIFA/cre/ERT2)Yunz page

Germline Transmission:	Earliest citation of germline transmission: J:292024
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J-Aw-J/J

Allele Type:    Targeted (Humanized sequence, Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gt(ROSA)26Sortm1.1(HIFA/cre/ERT2)Yunz expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gt(ROSA)26Sor (MGI:104735)   Mutation details: The targeting vector contains from 5' to 3': an adenovirus splice acceptor (SA), the oxygen-dependent degradation (ODD) domain from human HIF1A fused in-frame to the 5' end of Cre recombinase gene fused to the mutated estrogen receptor (cre/ERT2), a polyA tail, and an FRT-flanked neomycin cassette. The HIF1A ODD includes amino acids 371-653 containing prolines P401 and P564. The targeting vector was inserted into intron 1 of the Gt(ROSA)26Sor locus. (J:292024)

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Alliance mouse Gt(ROSA)26Sor gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:292024 Lin Q, et al., Generation of a hypoxia-sensing mouse model. Genesis. 2020 Mar;58(3-4):e23352
All:	1 reference(s)