Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Spp1tm1.1(cre/ERT2)Niba
Name:	secreted phosphoprotein 1; targeted mutation 1.1, Nick Barker
MGI ID:	MGI:6450712
Synonyms:	Spp1-eGFP-IRES-creERT2
Gene:	Spp1  Location: Chr5:104582984-104588916 bp, + strand  Genetic Position: Chr5, 50.68 cM
Alliance:	Spp1tm1.1(cre/ERT2)Niba page

Germline Transmission:	Earliest citation of germline transmission: J:292580
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Spp1tm1.1(cre/ERT2)Niba expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Spp1 (MGI:98389)   Mutation details: The following construct was inserted immediately after the ATG start codon: the EGFP fluorescent reporter gene, IRES sequence, a cre-ERT2 fusion gene, and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:292580)

Activity:	Tissue activity of this recombinase allele
Driver:	Spp1 (mouse) Summary of all recombinase alleles driven by Spp1. Comparative matrix view of recombinase activities Alliance mouse Spp1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spp1 Mutation:	40 strains or lines available

Original:	J:292580 Tan SH, et al., AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature. 2020 Feb;578(7795):437-443
All:	1 reference(s)