Gene Expression Data
Assay Details
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Assay
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Reference:
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J:50527
Jalbert LR, et al., Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest. 1998 Oct 15;102(8):1481-8
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:6450008
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Gene symbol:
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Fgb
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Gene name:
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fibrinogen beta chain
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Antibody:
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anti-fibrin(ogen) Nordic
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Detection system:
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Secondary antibody coupled to horseradish peroxidase
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Assay notes:
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The specificity of the antibody used was not detailed; all family members have been annotated.
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Results
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Specimen
2B:
(close  )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Mutant Allele(s):
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Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: telencephalon |
Present |
Regionally restricted |
2B
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Expressed in clotted vessels.
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Specimen
2D:
embryonic day 13.5
(more  )
Specimen
2D:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Specimen
2F:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Mutant Allele(s):
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Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: telencephalon |
Present |
Regionally restricted |
2F
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Expressed in clotted vessels, with a minor bleeding event near the lateral ventricle.
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Specimen
2H:
embryonic day 17.5
(more )
Specimen
2H:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Specimen
2J:
postnatal newborn
(more )
Specimen
2J:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Age:
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postnatal newborn
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: telencephalon |
Present |
Regionally restricted |
2J
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Expressed in clotted vessels in areas of extensive bleeding.
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Specimen
2L:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Mutant Allele(s):
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Proctm1Fjc/Proctm1Fjc
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Age:
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postnatal newborn
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Specimen
3B:
embryonic day 17.5
(more )
Specimen
3B:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: liver |
Present |
Widespread |
3B
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Widespread interstitial fibrin(ogen) deposition.
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Specimen
3D:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Mutant Allele(s):
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Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Specimen
3F:
postnatal newborn
(more )
Specimen
3F:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Age:
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postnatal newborn
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: liver |
Present |
Widespread |
3F
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Increased interstitial fibrin(ogen) deposition.
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Specimen
3H:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Mutant Allele(s):
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Proctm1Fjc/Proctm1Fjc
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Age:
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postnatal newborn
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Specimen
not shown:
postnatal newborn
(more )
Specimen
not shown:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Age:
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postnatal newborn
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: glomerular tuft |
Trace |
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Some traces of fibrin deposition were evident in the glomeruli and tubuli.
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| TS27: renal tubule |
Trace |
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Some traces of fibrin deposition were evident in the glomeruli and tubuli.
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| TS27: heart |
Present |
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Occasional clotting was seen.
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| TS27: lung |
Present |
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Occasional clotting was seen.
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Specimen
not shown:
embryonic day 13.5
(more )
Specimen
not shown:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * Swiss
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: liver |
Present |
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Some interstitial fibrin was observed.
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