Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Siglec1tm2(icre)Mtka
Name:	sialic acid binding Ig-like lectin 1, sialoadhesin; targeted mutation 2, Masato Tanaka
MGI ID:	MGI:6449968
Synonyms:	CD169-cre, Siglec1tm1(cre)Mtka
Gene:	Siglec1  Location: Chr2:130911140-130928685 bp, - strand  Genetic Position: Chr2, 63.26 cM, cytoband F-H1
Alliance:	Siglec1tm2(icre)Mtka page

Germline Transmission:	Earliest citation of germline transmission: J:286200
Parent Cell Line:	B6JN/1 (ES Cell)
Strain of Origin:	(C57BL/6N x C57BL/6J)F1

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Siglec1tm2(icre)Mtka expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Siglec1 (MGI:99668)   Mutation details: An improved Cre recombinase gene with a polyA tail and the neomycin resistance gene replaced the first 28-bp fragment including the endogenous ATG start site in exon 1 of the endogenous gene. (J:286200)

Activity:	Tissue activity of this recombinase allele
Driver:	Siglec1 (mouse) Summary of all recombinase alleles driven by Siglec1. Alliance mouse Siglec1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Siglec1 Mutation:	82 strains or lines available

Original:	J:286200 Karasawa K, et al., Vascular-resident CD169-positive monocytes and macrophages control neutrophil accumulation in the kidney with ischemia-reperfusion injury. J Am Soc Nephrol. 2015 Apr;26(4):896-906
All:	18 reference(s)